Transcription factor moonlights

metabolic syndrome and mitochondrial transcription factor a

Microtubules: MEC-17 Moonlights in the Lumen

New research characterizes a tubulin acetyltransferase that acts inside the microtubule lumen and has two separable activities that greatly affect microtubule architecture and functionality.

Cytokinesis: Centralspindlin Moonlights as a Membrane Anchor

The hardest working complex in animal cell division has a new gig. This extraordinary machine, the centralspindlin complex, works overtime, contributing to nearly every step in cytokinesis. It has now been shown to stabilize an association between the plasma membrane and the midbody microtubules prior to abscission.

APC Moonlights to Prevent Wnt Signalosome Assembly

The scaffold protein APC has a well-known function in ensuring β-catenin destruction. In this issue of Developmental Cell, Saito-Diaz et al. (2018) uncover another role for APC in Wnt signaling: to prevent clathrin-dependent signalosome formation in the absence of ligand.

Transcription factor functionality and transcription regulatory networks.

Now that numerous high-quality complete genome sequences are available, many efforts are focusing on the "second genomic code", namely the code that determines how the precise temporal and spatial expression of each gene in the genome is achieved. In this regard, the elucidation of transcription regulatory networks that describe combined transcriptional circuits for an organism of interest has ...